KALETRA FAQs

About KALETRA

What is KALETRA?

KALETRA is a prescription HIV-1 medicine that is used with other HIV medicines to treat HIV-1 (Human Immunodeficiency Virus) infection in adults and children 14 days of age and older. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome). KALETRA is a type of HIV medicine called a protease inhibitor. KALETRA contains two medicines: lopinavir and ritonavir. It is not known if KALETRA is safe and effective in children under 14 days old.

KALETRA does not cure HIV infection or AIDS. People taking KALETRA may develop infections or other conditions associated with HIV infection, including opportunistic infections (for example, pneumonia and herpes virus infections).

Learn more about KALETRA here

What is the most important information I should know about KALETRA?

KALETRA may cause serious side effects, including:

  • Interactions with other medicines. It is important to know the medicines that should not be taken with KALETRA. Read "Can I take KALETRA with other medicines?" in this FAQ.
  • Changes in your heart rhythm and the electrical activity of your heart. These changes may be seen on an EKG (electrocardiogram) and can lead to serious heart problems. Your risk for these problems may be higher if you:
    • Already have a history of abnormal heart rhythm or other types of heart disease
    • Take other medicines that can affect your heart rhythm while you take KALETRA.

Tell your doctor right away if you have any of these symptoms while taking KALETRA:

  • Dizziness
  • Light-headedness
  • Fainting
  • Sensation of abnormal heartbeats

See “What are the possible side effects of KALETRA?” in this FAQ for more information about serious side effects.

Click here for Important Safety Information about KALETRA.

How does KALETRA work?

HIV infection destroys CD4 cells, which are important to the immune system. After a large number of CD4 cells are destroyed, acquired immune deficiency syndrome (AIDS) develops.

KALETRA blocks HIV protease, a chemical needed for HIV to multiply. When used with other HIV medicines, KALETRA can help reduce the amount of HIV in your blood and can increase the number of CD4 cells. Reducing the amount of HIV in the blood and helping to raise the number of CD4 cells may reduce the chance of your HIV getting worse.

KALETRA does not cure HIV infection or AIDS. People taking KALETRA may develop infections or other conditions associated with HIV infection, including opportunistic infections (for example, pneumonia and herpes virus infections). You should remain under the care of a doctor when using KALETRA.

Learn more about KALETRA here

Who should not take KALETRA?

Do not take KALETRA if you are allergic to KALETRA or any of its ingredients, including lopinavir or ritonavir. Skin rashes, some of them severe, can occur in people who take KALETRA. Tell your doctor if you had a rash when you took another medicine for HIV or if you notice any skin rash when you take KALETRA. Do not take KALETRA if you are taking certain medicines. For more information about medicines you should not take with KALETRA, see "Can I take KALETRA with other medicines?" in this FAQs section and consult with your doctor about all other medicines you take.

Click here for Important Safety Information about KALETRA.

What should I tell my doctor before taking KALETRA?

Open communication between you and your doctor is an important part in taking an active role in your treatment. This is because taking HIV medications like KALETRA can carry serious risks.

KALETRA may not be right for you if you have certain medical conditions. Tell your doctor about any conditions you have, including if you:

  • Have any heart problems, including if you have a condition called Congenital Long QT Syndrome
  • Have or had pancreas problems
  • Have liver problems, including Hepatitis B or Hepatitis C
  • Have diabetes
  • Have hemophilia. People who take KALETRA may have increased bleeding
  • Have low potassium in your blood
  • Are pregnant or plan to become pregnant. You and your doctor should decide if KALETRA is right for you

Pregnancy Registry

There is a pregnancy registry for women who take antiretroviral medicines during pregnancy. The purpose of the pregnancy registry is to collect information about the health of you and your baby. Talk to your doctor about how you can take part in this registry.

  • Do not breastfeed. We do not know if KALETRA can be passed to the baby through your breast milk and whether it could harm your baby. Also, mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Many medicines interact with KALETRA. Do not start taking a new medicine without telling your doctor or pharmacist. Your doctor can tell you if it is safe to take KALETRA with other medicines. Your doctor may need to change the dose of other medicines while you take KALETRA.

Get more tips about how to get the most out of each doctor visit here

Click here for Important Safety Information about KALETRA.

What are the possible side effects of KALETRA?

Common side effects of KALETRA include diarrhea, nausea, increased fats in blood (triglycerides or cholesterol), or vomiting.

See also “What is the most important information I should know about KALETRA?” in this FAQ.

KALETRA can cause serious side effects including:

Interactions with other medicines. It is important to know the medicines that should not be taken with KALETRA.

  • Inflammation of the pancreas (pancreatitis). Some people who take KALETRA get inflammation of the pancreas, which may be serious and cause death. You have a higher chance of getting pancreatitis if you have had it before. Tell your doctor if you have nausea, vomiting, or abdominal pain while taking KALETRA. These may be signs of pancreatitis
  • Liver Problems. Liver problems, including death, can happen in people who take KALETRA. Your doctor should do blood tests before and during your treatment with KALETRA to check your liver function. Some people with liver disease such as Hepatitis B and Hepatitis C who take KALETRA may have worsening liver disease. Tell your doctor right away if you have any of these signs and symptoms of liver problems:
    • Loss of appetite
    • Yellow skin and whites of eyes (jaundice)
    • Dark-colored urine
    • Pale-colored stools
    • Itchy skin
    • Stomach area (abdominal) pain
  • Diabetes and high blood sugar (hyperglycemia). Some people who take protease inhibitors including KALETRA get new or more serious diabetes, or high blood sugar. Tell your doctor if you notice an increase in thirst or urinate often while taking KALETRA
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Call your doctor right away if you start having new symptoms after starting your HIV medicine
  • Increases in certain fat (triglycerides and cholesterol) levels in your blood. Large increases of triglycerides and cholesterol can be seen in blood test results of some people who take KALETRA. Your doctor should do blood tests to check your cholesterol and triglyceride levels before you start taking KALETRA and during your treatment
  • Changes in body fat. Changes in body fat may occur in some people who take antiretroviral therapy. These changes may include increased amount of fat in the upper back and neck ("buffalo hump"), breast, and around the trunk. Loss of fat from the legs, arms and face may also happen. The cause and long-term health effects of these conditions are not known at this time
  • Increased bleeding for hemophiliacs. Some people with hemophilia have increased bleeding with protease inhibitors including KALETRA
  • Increased risk of certain problems when you take KALETRA with medicines used for the treatment of erectile problems such as avanafil (Stendra®), sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®), including:
    • Low blood pressure. If you get dizzy or faint, you need to lie down. Tell your doctor if you feel dizzy or have fainting spells
    • Vision changes. Tell your doctor right away if you have vision changes
    • Penis erection lasting more than 4 hours. If you have an erection that lasts longer than 4 hours, get medical help right away to avoid permanent damage to your penis. Your doctor can explain these symptoms to you
  • Allergic reactions. Skin rashes, some of them severe, can occur in people who take KALETRA. Tell your healthcare provider if you had a rash when you took another medicine for your HIV infection or if you notice any skin rash when you take KALETRA.
  • Babies taking KALETRA oral solution may have side effects. KALETRA oral solution contains propylene glycol and a large amount of alcohol. KALETRA oral solution should not be given to babies younger than 14 days of age unless your doctor thinks it is right for your baby. Call your doctor right away if your baby appears too sleepy or their breathing has changed
  • KALETRA oral solution contains propylene glycol and a large amount of alcohol. Talk with your doctor if you take or plan to take metronidazole or disulfiram. You can have severe nausea and vomiting if you take these medicines with KALETRA

These are not all of the possible side effects of KALETRA. For more information, ask your doctor or pharmacist. If you do experience side effects, talk to your doctor. Do not stop taking your HIV medicines without discussing it with your doctor first.

You may report side effects to the FDA at 1-800-FDA-1088.

Click here for Important Safety Information about KALETRA.

How to take KALETRA

Can I take KALETRA with other medicines?

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, heartburn medicines, vitamins, and herbal supplements. Many medicines can become dangerous when taken with KALETRA. Do not start taking a new medicine without telling your doctor or pharmacist. Your doctor can tell you if it is safe to take KALETRA with other medicines. Your doctor may need to change the dose of other medicines while you take KALETRA.

Do not take KALETRA if you take any of the following medicines:

  • Alfuzosin (Uroxatral®)
  • Cisapride (Propulsid®, Quicksolv®)
  • Ergot-containing medicines including
    • Ergotamine tartrate (Cafergot®, Migergot®, Ergomar®, Ergostat®, Medihaler®, Ergotamine, Wigraine®, Wigrettes®)
    • Dihydroergotamine mesylate (D.H.E. 45®, Migranal®)
    • Methylergonovine (Methergine®)
  • Lovastatin (Advicor®, Altoprev®, Mevacor®)
  • Midazolam oral syrup
  • Pimozide (Orap®)
  • Rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®)
  • Sildenafil (Revatio®), when used for the treatment of pulmonary arterial hypertension
  • Simvastatin (Zocor®, Vytorin®, Simcor®)
  • St. John’s wort (Hypericum perforatum)
  • Triazolam (Halcion®)

Serious problems can happen if you or your child takes any of the medicines listed above with KALETRA.

  • Do not take KALETRA if you are allergic to lopinavir, ritonavir, or any of the ingredients in KALETRA.

Tell your doctor right away if you are taking:

  • Estrogen-based contraceptives (birth control pills and patches). You should use a different type or an extra form of birth control, since birth control pills or patches may not work as well while you take KALETRA. Talk to your doctor about how to prevent pregnancy while taking KALETRA
  • Medicines used for the treatment of erectile problems, such as avanafil (Stendra®), sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®). There is an increased risk of certain problems when you take these medicines with KALETRA, such as low blood pressure (dizziness or fainting), vision changes, and/or erections lasting more than 4 hours. Tell your doctor right away if you experience any of these side effects
  • KALETRA oral solution contains propylene glycol and a large amount of alcohol. Talk with your doctor if you take or plan to take metronidazole or disulfiram. You can have severe nausea and vomiting if you take these medicines with KALETRA

The above list of medicines is not complete. Please refer to the "What should I tell my doctor before taking KALETRA" section of the Medication Guide for a list of medicines that may require your therapy to be monitored more closely or may require a change in dose or dose schedule of KALETRA (lopinavir/ritonavir) or the other medicine. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

Click here for the Medication Guide for KALETRA.

Registered trademarks listed are the property of their respective companies.

Click here for Important Safety Information about KALETRA.

Should I take KALETRA once a day or twice a day?

Some adults with HIV can take KALETRA once daily, while others should take it twice daily.

Changes to your dosing schedule should only start after talking with your doctor. Follow the directions from your doctor exactly. Talk to your doctor about which option may be right for you.

KALETRA should not be taken once daily with the following HIV medicines: efavirenz (Atripla® and Sustiva®), nevirapine (Viramune®), or nelfinavir (Viracept®).

KALETRA should not be taken once daily with these medicines as well: carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®), phenobarbital (Luminal®), or phenytoin (Dilantin®, Phenytek®).

KALETRA tablets should not be taken once daily if you are pregnant

KALETRA should not be given once daily in children.

There may be a greater chance of developing diarrhea with the once-daily regimen as compared with the twice-daily regimen.

Find more information about once-daily dosing option here.

Find more information about twice-daily dosing option here.

How should I take KALETRA?

Take KALETRA every day exactly as prescribed by your doctor. It is very important to set up a dosing schedule and follow it every day. (See Sticking to Your Treatment Plan.)

Do not change your treatment or stop treatment without first talking with your doctor. When taking KALETRA, here are some general tips to remember:

  • KALETRA can be taken with acid-reducing agents used for heartburn or reflux such as Prilosec® (omeprazole) and Zantac® (ranitidine) with no dose adjustment.
  • If you take more than the prescribed dose of KALETRA, call your local poison control center or emergency room right away.
  • If KALETRA is being used for your child, tell your doctor if your child's weight changes.
  • KALETRA should not be given one time each day in children under 18 years of age. When giving KALETRA to your child, give KALETRA exactly as prescribed.
  • KALETRA should not be taken once daily if you take carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®), phenobarbital (Luminal®), or phenytoin (Dilantin®, Phenytek®). KALETRA also should not be taken once daily with the following HIV medicines: efavirenz (Atripla®, Sustiva®), nevirapine (Viramune®), or nelfinavir (Viracept®)
  • If you are taking both didanosine (Videx®) and KALETRA:
    • Didanosine can be taken at the same time as KALETRA tablets, without food.
    • Take didanosine either one hour before or two hours after taking KALETRA oral solution.

When taking KALETRA tablets:

  • Swallow KALETRA tablets whole. Do not chew, break, or crush KALETRA tablets.
  • KALETRA tablets can be taken with or without food.

If you are unable to take KALETRA in tablet form, KALETRA is also available as an oral solution. When taking KALETRA oral solution:

  • Take KALETRA oral solution with food to help it work better.
  • KALETRA oral solution should not be taken if you are pregnant.
  • KALETRA oral solution contains propylene glycol and a large amount of alcohol.
    • KALETRA oral solution should not be given to babies younger than 14 days of age unless your doctor thinks it is right for your baby. Babies taking KALETRA oral solution may have side effects. Call your doctor right away if your baby appears too sleepy or their breathing has changed.
    • If a young child drinks more than the recommended dose, it could make them sick. Contact your local poison control center or emergency room right away.
    • Talk with your doctor if you take or plan to take metronidazole or disulfiram. You can have severe nausea and vomiting if you take these medicines with KALETRA.

Click here for Important Safety Information about KALETRA.

How should I store KALETRA?

KALETRA tablets:

  • Store KALETRA tablets at room temperature, between 59°F to 86°F (15°C to 30°C)
  • Do not keep KALETRA tablets out of the container it comes in for longer than 2 weeks, especially in areas where there is a lot of humidity. Keep the container closed tightly

KALETRA oral solution:

  • Store KALETRA oral solution in a refrigerator, between 36°F to 46°F (2°C to 8°C)
  • KALETRA oral solution that is kept refrigerated may be used until the expiration date printed on the label
  • KALETRA oral solution that is stored at room temperature (less than 77°F or 25°C) should be used within 2 months
  • Keep KALETRA away from high heat

Throw away any medicine that is out of date or that you no longer need.

Keep KALETRA and all medicines out of the reach of children.

Click here for Important Safety Information about KALETRA.

What should I do if I miss a dose of KALETRA?

It is very important that you never miss a dose of KALETRA. This could make the virus harder to treat.

But if you miss a dose of KALETRA:

  • Do take the missed dose right away.
  • Don’t take the missed dose if it is almost time for your next dose. Instead, follow your regular dosing schedule by taking your next dose at its regular time.
  • Don't take more than one dose of KALETRA at one time.

Taking your medications exactly as prescribed by your doctor, every time, is one of the most important things you can do to help control your HIV.

Find tips and information that can help you stick to your treatment plan here.

What should I do if I take too much KALETRA?

If you take more than the prescribed dose of KALETRA, call your local poison control center or emergency room right away.

KALETRA oral solution contains propylene glycol and a large amount of alcohol. If a young child drinks more than the recommended dose, it could make them sick. Contact your local poison control center or emergency room right away.

  • KALETRA oral solution should not be given to babies younger than 14 days of age unless your doctor thinks it is right for your baby. Babies taking KALETRA oral solution may have side effects. Call your doctor right away if your baby appears too sleepy or their breathing has changed

Click here for Important Safety Information about KALETRA.

KALETRA and HIV

Is KALETRA a cure for HIV or AIDS?

No HIV medication, including KALETRA, can cure HIV or AIDS.

KALETRA does not cure HIV infection or AIDS. People taking KALETRA may develop infections or other conditions associated with HIV infection, including opportunistic infections (for example, pneumonia and herpes virus infections). Learn more about HIV and how it affects your body here.

You and your doctor will set specific medical goals for your HIV treatment. Learn more about the goals of HIV treatment here.

Does KALETRA reduce the risk of passing HIV to others?

No. KALETRA does not stop you from passing HIV to others.

Avoid doing things that can spread HIV-1 infection.

  • Do not share needles or other injection equipment
  • Do not share personal items that can have blood or body fluids on them, like toothbrushes and razor blades
  • Do not have any kind of sex without protection. Always practice safe sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood

Get the facts about HIV and how it can be passed from one person to another here.

Support

Is there a program to help support me in managing my HIV therapy?

YES! And it’s called the YES Program.

You
Empowered
Supported

The YES Program offers many confidential benefits specially designed to help support you during your treatment with KALETRA:

  • Nurse ambassadors* available 24 hours a day to answer your KALETRA and HIV questions
  • Co-pay Program, if eligible most patients who are commercially insured or pay retail (cash) can save up to $400 a month on KALETRA with the Co-pay Program
  • KALETRA prescription refill reminders sent by text message or email
  • Email Connect Series, emails featuring useful information and management tips

Sign up now and say YES to the patient support program created for you.

Talking with your doctor is a great way to stay informed and motivated.

See what questions you can ask to help get the most out of each doctor visit.

Be the voice and inspiration for other patients by calling 1-855-971-0540
or contact info@speaknetwork.net. Share your story today

Use: KALETRA® (lopinavir/ritonavir)

What is KALETRA?

KALETRA® (lopinavir/ritonavir) is a prescription HIV-1 medicine that is used with other HIV medicines to treat HIV-1 (Human Immunodeficiency Virus) infection in adults and children 14 days of age and older. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome). KALETRA is a type of HIV medicine called a protease inhibitor. KALETRA contains two medicines: lopinavir and ritonavir. It is not known if KALETRA is safe and effective in children under 14 days old.

KALETRA does not cure HIV infection or AIDS. People taking KALETRA may develop infections or other conditions associated with HIV infection, including opportunistic infections (for example, pneumonia and herpes virus infections).


Important Safety Information

What is the most important information I should know about KALETRA?

KALETRA may cause serious side effects, including:
Interactions with other medicines. It is important to know the medicines that should not be taken with KALETRA. For more information, see “Who should not take KALETRA?”

Changes in your heart rhythm and the electrical activity of your heart can occur when taking KALETRA. These changes can lead to serious heart problems. Your risk for these problems may be higher if you already have a history of abnormal heart rhythm or other types of heart disease, or if you take other medicines that can affect your heart rhythm while you take KALETRA. Tell your doctor right away if you experience dizziness, lightheadedness, fainting, and/or a sensation of abnormal heartbeats.

Who should not take KALETRA?

Do not take KALETRA if you are allergic to KALETRA or any of its ingredients, including lopinavir or ritonavir. Skin rashes, some of them severe, can occur in people who take KALETRA. Tell your doctor if you had a rash when you took another medicine for HIV or if you notice any skin rash when you take KALETRA.

Do not take KALETRA if you take any of the following medicines: alfuzosin (Uroxatral®); cisapride (Propulsid®, Quicksolv®); ergot containing medicines, including ergotamine (Cafergot® and others), dihydroergotamine (D.H.E. 45® or Migranal®), and methylergonovine (Methergine®); lovastatin (Advicor®, Altoprev®, or Mevacor®); midazolam oral syrup; pimozide (Orap®); rifampin (Rifadin®, Rifamate®, Rifater®, or Rimactane®); sildenafil (Revatio®), when used for the treatment of pulmonary arterial hypertension; simvastatin (Zocor®, Vytorin®, or Simcor®); products containing St. John’s Wort (Hypericum perforatum); or triazolam (Halcion®).

Serious problems can happen if you or your child takes any of the medicines listed above with KALETRA.

What should I tell my doctor before taking KALETRA?

KALETRA may not be right for you. Tell your doctor about all of your medical conditions, including if you have any heart problems, including if you have a condition called congenital long QT syndrome; have or had pancreas problems, liver problems, including hepatitis B or hepatitis C, diabetes, hemophilia (people who take KALETRA may have increased bleeding), or low potassium in your blood; or are pregnant or plan to become pregnant.

If you take KALETRA during pregnancy, you should talk with your doctor about how you can take part in an Antiretroviral Pregnancy Registry.

Do not breastfeed, as it is not known if KALETRA can be passed to the baby through your breast milk and whether it could harm your baby. Also, mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Many medicines interact with KALETRA. Do not start taking a new medicine without telling your doctor or pharmacist. Your doctor can tell you if it is safe to take KALETRA with other medicines. Your doctor may need to change the dose of other medicines while you take KALETRA. Tell your doctor right away if you are taking:

  • Estrogen-based contraceptives (birth control pills and patches). You should use a different type or an extra form of birth control, since birth control pills or patches may not work as well while you take KALETRA. Talk to your doctor about how to prevent pregnancy while taking KALETRA.
  • Medicines used for the treatment of erectile problems, such as avanafil (Stendra®), sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®). There is an increased risk of certain problems when you take these medicines with KALETRA, such as low blood pressure (dizziness or fainting), vision changes, and/or erections lasting more than 4 hours. Tell your doctor right away if you experience any of these side effects.

KALETRA should not be taken once daily if you take carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®, Phenytek®), efavirenz (Atripla®, Sustiva®), nevirapine (Viramune®), or nelfinavir (Viracept®).

KALETRA tablets should not be taken once daily if you are pregnant. You should not take KALETRA oral solution if you are pregnant.

KALETRA oral solution contains propylene glycol and a large amount of alcohol.

  • KALETRA oral solution should not be given to babies younger than 14 days of age unless your doctor thinks it is right for your baby. Babies taking KALETRA oral solution may have side effects. Call your doctor right away if your baby appears too sleepy or their breathing has changed.
  • Talk with your doctor if you take or plan to take metronidazole or disulfiram. You can have severe nausea and vomiting if you take these medicines with KALETRA.

This is not a complete list of medicines about which you should tell your doctor or pharmacist. For more information, refer to the KALETRA Medication Guide. Ask your doctor or pharmacist if you are not sure what medicines you are taking. Know all the medicines that you take. Keep a list of them to show doctors and pharmacists when you get a new medicine. Do not start any new medicines while you are taking KALETRA without first talking with your doctor.

What are the possible side effects of KALETRA?

KALETRA can cause serious side effects:
KALETRA may not be right for you. Tell your doctor about all of your medical conditions.

Inflammation of the pancreas (pancreatitis), which may be serious and cause death, has occurred in some people who take KALETRA. You have a higher chance of having pancreatitis if you have had it before. Tell your doctor if you have nausea, vomiting, and/or abdominal pain, as these may be signs of pancreatitis.

Liver problems, including death, can happen in people who take KALETRA. Your doctor should do blood tests before and during your treatment with KALETRA to check your liver function. Some people with liver disease, such as hepatitis B or C, who take KALETRA may have worsening liver disease. Tell your doctor right away if you have any of the following signs and symptoms: loss of appetite, yellowing of skin or eyes (jaundice), dark-colored urine, pale-colored stools, itchy skin, and/or stomach area (abdominal) pain.

New or more serious diabetes and high blood sugar (hyperglycemia) have occurred in some people who take protease inhibitors, including KALETRA. Tell your doctor if you notice an increase in thirst or urinate often while taking KALETRA.

Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Call your doctor right away if you start having new symptoms after starting your HIV medicine.

Large increases in certain fat (triglycerides and cholesterol) levels in the blood have occurred in some people receiving KALETRA. Your doctor should do blood tests to check your cholesterol and triglyceride levels before you start taking KALETRA and during your treatment.

Changes in body fat have been seen in some people who take anti-HIV therapy. The cause and long-term health effects of these conditions are not known at this time.

Increased bleeding has occurred in some people with hemophilia who take protease inhibitors, including KALETRA.

Common side effects of KALETRA include diarrhea, nausea, increased fats in blood (triglycerides or cholesterol), and vomiting. These are not all of the possible side effects of KALETRA.

This is the most important information to know about KALETRA. For more information, talk with your doctor.

Reference:
KALETRA [package insert]. 1697387-1741904